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THE PLANT CELL, Vol 9, Issue 4 641-651, Copyright © 1997 by American Society of Plant Biologists

RESEARCH ARTICLE

Inactivation of the Flax Rust Resistance Gene M Associated with Loss of a Repeated Unit within the Leucine-Rich Repeat Coding Region

P. A. Anderson, G. J. Lawrence, B. C. Morrish, M. A. Ayliffe, E. J. Finnegan and J. G. Ellis
Commonwealth Scientific and Industrial Research Organization, Division of Plant Industry, GPO Box 1600, Canberra, A.C.T., 2601, Australia

The M rust resistance gene from flax was cloned after two separate approaches, an analysis of spontaneous M mutants with an L6 gene-derived DNA probe and tagging with the maize transposon Activator, independently identified the same gene. The gene encodes a protein of the nucleotide binding site leucine-rich repeat class and is related (86% nucleotide identity) to the unlinked L6 rust resistance gene. In contrast to the L locus, which contains a single gene with multiple alleles, ~15 related genes occur at the complex M locus, with only one encoding the M resistance specificity. The M protein contains two direct repeats of 147 and 149 amino acids in the C-terminal part of the leucine-rich region. Three mutant alleles of M encoding a product containing a single repeat unit of 154 amino acids were isolated. The mutant DNA sequences probably occurred by unequal intragenic exchange in the coding region of the repeats. The recombinant alleles lost M resistance and gained no detectable new resistance specificity.


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