Plant Cell Applied Biosystems SYBR(R) Cells-to-CT(TM) Kits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online July 23, 2004; 10.1105/tpc.104.022616

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
16/8/2128    most recent
tpc.104.022616v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (76)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Price, J.
Right arrow Articles by Jang, J.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Price, J.
Right arrow Articles by Jang, J.-C.
Agricola
Right arrow Articles by Price, J.
Right arrow Articles by Jang, J.-C.
The Plant Cell 16:2128-2150 (2004)
© 2004 American Society of Plant Biologists

Global Transcription Profiling Reveals Multiple Sugar Signal Transduction Mechanisms in Arabidopsis

John Pricea, Ashverya Laxmia, Steven K. St. Martina and Jyan-Chyun Janga,b,1

a Department of Horticulture and Crop Science, The Ohio State University, Columbus, Ohio 43210
b Department of Plant Cellular and Molecular Biology, The Ohio State University, Columbus, Ohio 43210

1 To whom correspondence should be addressed. E-mail jang.40{at}osu.edu; fax 614-292-5379.

Complex and interconnected signaling networks allow organisms to control cell division, growth, differentiation, or programmed cell death in response to metabolic and environmental cues. In plants, it is known that sugar and nitrogen are critical nutrient signals; however, our understanding of the molecular mechanisms underlying nutrient signal transduction is very limited. To begin unraveling complex sugar signaling networks in plants, DNA microarray analysis was used to determine the effects of glucose and inorganic nitrogen source on gene expression on a global scale in Arabidopsis thaliana. In whole seedling tissue, glucose is a more potent signal in regulating transcription than inorganic nitrogen. In fact, other than genes associated with nitrate assimilation, glucose had a greater effect in regulating nitrogen metabolic genes than nitrogen itself. Glucose also regulated a broader range of genes, including genes associated with carbohydrate metabolism, signal transduction, and metabolite transport. In addition, a large number of stress responsive genes were also induced by glucose, indicating a role of sugar in environmental responses. Cluster analysis revealed significant interaction between glucose and nitrogen in regulating gene expression because glucose can modulate the effects of nitrogen and vise versa. Intriguingly, cycloheximide treatment appeared to disrupt glucose induction more than glucose repression, suggesting that de novo protein synthesis is an intermediary event required before most glucose induction can occur. Cross talk between sugar and ethylene signaling may take place on the transcriptional level because several ethylene biosynthetic and signal transduction genes are repressed by glucose, and the repression is largely unaffected by cycloheximide. Collectively, our global expression data strongly support the idea that glucose and inorganic nitrogen act as both metabolites and signaling molecules.




This article has been cited by other articles:


Home page
 J Exp BotHome page
C. Castro, M. Motto, V. Rossi, and C. Manetti
Variation of metabolic profiles in developing maize kernels up- and down-regulated for the hda101 gene
J. Exp. Bot., October 10, 2008; (2008) ern239v2.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
C. D. Mara and V. F. Irish
Two GATA Transcription Factors Are Downstream Effectors of Floral Homeotic Gene Action in Arabidopsis
Plant Physiology, June 1, 2008; 147(2): 707 - 718.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
R. Vidhyavathi, L. Venkatachalam, R. Sarada, and G. A. Ravishankar
Regulation of carotenoid biosynthetic genes expression and carotenoid accumulation in the green alga Haematococcus pluvialis under nutrient stress conditions
J. Exp. Bot., April 1, 2008; 59(6): 1409 - 1418.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. A. Tronconi, H. Fahnenstich, M. C. Gerrard Weehler, C. S. Andreo, U.-I. Flugge, M. F. Drincovich, and V. G. Maurino
Arabidopsis NAD-Malic Enzyme Functions As a Homodimer and Heterodimer and Has a Major Impact on Nocturnal Metabolism
Plant Physiology, April 1, 2008; 146(4): 1540 - 1552.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
L. Lejay, J. Wirth, M. Pervent, J. M.-F. Cross, P. Tillard, and A. Gojon
Oxidative Pentose Phosphate Pathway-Dependent Sugar Sensing as a Mechanism for Regulation of Root Ion Transporters by Photosynthesis
Plant Physiology, April 1, 2008; 146(4): 2036 - 2053.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
B. Usadel, O. E. Blasing, Y. Gibon, K. Retzlaff, M. Hohne, M. Gunther, and M. Stitt
Global Transcript Levels Respond to Small Changes of the Carbon Status during Progressive Exhaustion of Carbohydrates in Arabidopsis Rosettes
Plant Physiology, April 1, 2008; 146(4): 1834 - 1861.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
R. Balasubramanian, A. Karve, M. Kandasamy, R. B. Meagher, and B. d. Moore
A Role for F-Actin in Hexokinase-Mediated Glucose Signaling
Plant Physiology, December 1, 2007; 145(4): 1423 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
F. A. Hoeberichts, W. G. van Doorn, O. Vorst, R. D. Hall, and M. F. van Wordragen
Sucrose prevents up-regulation of senescence-associated genes in carnation petals
J. Exp. Bot., August 1, 2007; 58(11): 2873 - 2885.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
Y. Li, C. Smith, F. Corke, L. Zheng, Z. Merali, P. Ryden, P. Derbyshire, K. Waldron, and M. W. Bevan
Signaling from an Altered Cell Wall to the Nucleus Mediates Sugar-Responsive Growth and Development in Arabidopsis thaliana
PLANT CELL, August 1, 2007; 19(8): 2500 - 2515.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
R. A. Gutierrez, M. L. Gifford, C. Poultney, R. Wang, D. E. Shasha, G. M. Coruzzi, and N. M. Crawford
Insights into the genomic nitrate response using genetics and the Sungear Software System
J. Exp. Bot., July 1, 2007; 58(9): 2359 - 2367.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
A. K. Grennan
The Role of Trehalose Biosynthesis in Plants
Plant Physiology, May 1, 2007; 144(1): 3 - 5.
[Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
E.-J. Lee, Y. Matsumura, K. Soga, T. Hoson, and N. Koizumi
Glycosyl Hydrolases of Cell Wall are Induced by Sugar Starvation in Arabidopsis
Plant Cell Physiol., March 1, 2007; 48(3): 405 - 413.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
R. Muller, M. Morant, H. Jarmer, L. Nilsson, and T. H. Nielsen
Genome-Wide Analysis of the Arabidopsis Leaf Transcriptome Reveals Interaction of Phosphate and Sugar Metabolism
Plant Physiology, January 1, 2007; 143(1): 156 - 171.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
J. M. Cross, M. von Korff, T. Altmann, L. Bartzetko, R. Sulpice, Y. Gibon, N. Palacios, and M. Stitt
Variation of Enzyme Activities and Metabolite Levels in 24 Arabidopsis Accessions Growing in Carbon-Limited Conditions
Plant Physiology, December 1, 2006; 142(4): 1574 - 1588.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
F. Calenge, V. Saliba-Colombani, S. Mahieu, O. Loudet, F. Daniel-Vedele, and A. Krapp
Natural Variation for Carbohydrate Content in Arabidopsis. Interaction with Complex Traits Dissected by Quantitative Genetics
Plant Physiology, August 1, 2006; 141(4): 1630 - 1643.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. Nicolai, M.A. Roncato, A.S. Canoy, D. Rouquie, X. Sarda, G. Freyssinet, and C. Robaglia
Large-Scale Analysis of mRNA Translation States during Sucrose Starvation in Arabidopsis Cells Identifies Cell Proliferation and Chromatin Structure as Targets of Translational Control
Plant Physiology, June 1, 2006; 141(2): 663 - 673.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
Y. Li, K. K. Lee, S. Walsh, C. Smith, S. Hadingham, K. Sorefan, G. Cawley, and M. W. Bevan
Establishing glucose- and ABA-regulated transcription networks in Arabidopsis by microarray analysis and promoter classification using a Relevance Vector Machine
Genome Res., March 1, 2006; 16(3): 414 - 427.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
I. Couee, C. Sulmon, G. Gouesbet, and A. El Amrani
Involvement of soluble sugars in reactive oxygen species balance and responses to oxidative stress in plants
J. Exp. Bot., February 1, 2006; 57(3): 449 - 459.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
R. S. Quilliam, P. J. Swarbrick, J. D. Scholes, and S. A. Rolfe
Imaging photosynthesis in wounded leaves of Arabidopsis thaliana
J. Exp. Bot., January 1, 2006; 57(1): 55 - 69.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
A. Wingler, S. Purdy, J. A. MacLean, and N. Pourtau
The role of sugars in integrating environmental signals during the regulation of leaf senescence
J. Exp. Bot., January 1, 2006; 57(2): 391 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
O. E. Blasing, Y. Gibon, M. Gunther, M. Hohne, R. Morcuende, D. Osuna, O. Thimm, B. Usadel, W.-R. Scheible, and M. Stitt
Sugars and Circadian Regulation Make Major Contributions to the Global Regulation of Diurnal Gene Expression in Arabidopsis
PLANT CELL, December 1, 2005; 17(12): 3257 - 3281.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
Z. Xin, Y. Zhao, and Z.-L. Zheng
Transcriptome Analysis Reveals Specific Modulation of Abscisic Acid Signaling by ROP10 Small GTPase in Arabidopsis
Plant Physiology, November 1, 2005; 139(3): 1350 - 1365.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
C. J. Baxter, M. Sabar, W. P. Quick, and L. J. Sweetlove
Comparison of changes in fruit gene expression in tomato introgression lines provides evidence of genome-wide transcriptional changes and reveals links to mapped QTLs and described traits
J. Exp. Bot., June 1, 2005; 56(416): 1591 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
J. M. Franco-Zorrilla, A. C. Martin, A. Leyva, and J. Paz-Ares
Interaction between Phosphate-Starvation, Sugar, and Cytokinin Signaling in Arabidopsis and the Roles of Cytokinin Receptors CRE1/AHK4 and AHK3
Plant Physiology, June 1, 2005; 138(2): 847 - 857.
[Abstract] [Full Text] [PDF]

Home page
 ANN BOT (LOND)Home page
Y.-F. CHEN, N. ETHERIDGE, and G. E. SCHALLER
Ethylene Signal Transduction
Ann. Bot., May 1, 2005; 95(6): 901 - 915.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 2004 by the American Society of Plant Biologists