Plant Cell Drug Metab Dispos
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online March 22, 2004; 10.1105/tpc.018754

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
16/4/1021    most recent
tpc.018754v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (55)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Probst, A. V.
Right arrow Articles by Scheid, O. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Probst, A. V.
Right arrow Articles by Scheid, O. M.
Agricola
Right arrow Articles by Probst, A. V.
Right arrow Articles by Scheid, O. M.
The Plant Cell 16:1021-1034 (2004)
© 2004 American Society of Plant Biologists

Arabidopsis Histone Deacetylase HDA6 Is Required for Maintenance of Transcriptional Gene Silencing and Determines Nuclear Organization of rDNA Repeats

Aline V. Probsta,b,1, Mathilde Fagardc,2, Florence Prouxc,3, Philippe Mourrainc,4, Stéphanie Boutetc,5, Keith Earleyd, Richard J. Lawrenced, Craig S. Pikaardd, Jane Murfette, Ian Furnerf, Hervé Vaucheretc and Ortrun Mittelsten Scheida,6

a Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland
b Laboratory of Plant Genetics, University of Geneva, CH-1211 Geneva 4, Switzerland
c Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, F-78026 Versailles Cedex, France
d Biology Department, Washington University, St. Louis, Missouri 63130
e Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211
f Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom

1 To whom correspondence should be addressed. E-mail aline.probst{at}bioveg.unige.ch; fax 41-22-379-31-07.

Histone acetylation and deacetylation are connected with transcriptional activation and silencing in many eukaryotic organisms. Gene families for enzymes that accomplish these modifications show a surprising multiplicity in sequence and expression levels, suggesting a high specificity for different targets. We show that mutations in Arabidopsis (Arabidopsis thaliana) HDA6, a putative class I histone deacetylase gene, result in loss of transcriptional silencing from several repetitive transgenic and endogenous templates. Surprisingly, total levels of histone H4 acetylation are only slightly affected, whereas significant hyperacetylation is restricted to the nucleolus organizer regions that contain the rDNA repeats. This switch coincides with an increase of histone 3 methylation at Lys residue 4, a modified DNA methylation pattern, and a concomitant decondensation of the chromatin. These results indicate that HDA6 might play a role in regulating activity of rRNA genes, and this control might be functionally linked to silencing of other repetitive templates and to its previously assigned role in RNA-directed DNA methylation.




This article has been cited by other articles:


Home page
 J Exp BotHome page
C. Castro, M. Motto, V. Rossi, and C. Manetti
Variation of metabolic profiles in developing maize kernels up- and down-regulated for the hda101 gene
J. Exp. Bot., October 10, 2008; (2008) ern239v2.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
K. Wu, L. Zhang, C. Zhou, C.-W. Yu, and V. Chaikam
HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis
J. Exp. Bot., February 1, 2008; 59(2): 225 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. Tanaka, A. Kikuchi, and H. Kamada
The Arabidopsis Histone Deacetylases HDA6 and HDA19 Contribute to the Repression of Embryonic Properties after Germination
Plant Physiology, January 1, 2008; 146(1): 149 - 161.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
R. Matyasek, J. A. Tate, Y. K. Lim, H. Srubarova, J. Koh, A. R. Leitch, D. E. Soltis, P. S. Soltis, and A. Kovarik
Concerted Evolution of rDNA in Recently Formed Tragopogon Allotetraploids Is Typically Associated With an Inverse Correlation Between Gene Copy Number and Expression
Genetics, August 1, 2007; 176(4): 2509 - 2519.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
I. Vaillant, S. Tutois, C. Cuvillier, I. Schubert, and S. Tourmente
Regulation of Arabidopsis thaliana 5S rRNA Genes
Plant Cell Physiol., May 1, 2007; 48(5): 745 - 752.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
I. Grummt
Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes
Hum. Mol. Genet., April 15, 2007; 16(R1): R21 - R27.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
V. Rossi, S. Locatelli, S. Varotto, G. Donn, R. Pirona, D. A. Henderson, H. Hartings, and M. Motto
Maize Histone Deacetylase hda101 Is Involved in Plant Development, Gene Transcription, and Sequence-Specific Modulation of Histone Modification of Genes and Repeats
PLANT CELL, April 1, 2007; 19(4): 1145 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
X. Yang, L. Timofejeva, H. Ma, and C. A. Makaroff
The Arabidopsis SKP1 homolog ASK1 controls meiotic chromosome remodeling and release of chromatin from the nuclear membrane and nucleolus
J. Cell Sci., September 15, 2006; 119(18): 3754 - 3763.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
C. Li, J. E. Mueller, and M. Bryk
Sir2 Represses Endogenous Polymerase II Transcription Units in the Ribosomal DNA Nontranscribed Spacer
Mol. Biol. Cell, September 1, 2006; 17(9): 3848 - 3859.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
K. M. McGinnis, C. Springer, Y. Lin, C. C. Carey, and V. Chandler
Transcriptionally Silenced Transgenes in Maize Are Activated by Three Mutations Defective in Paramutation
Genetics, July 1, 2006; 173(3): 1637 - 1647.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
B. McStay
Nucleolar dominance: a model for rRNA gene silencing.
Genes & Dev., May 15, 2006; 20(10): 1207 - 1214.
[Full Text] [PDF]

Home page
 Genes Dev.Home page
K. Earley, R. J. Lawrence, O. Pontes, R. Reuther, A. J. Enciso, M. Silva, N. Neves, M. Gross, W. Viegas, and C. S. Pikaard
Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance
Genes & Dev., May 15, 2006; 20(10): 1283 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
T. Ono, H. Kaya, S. Takeda, M. Abe, Y. Ogawa, M. Kato, T. Kakutani, O. M. Scheid, T. Araki, and K.-i. Shibahara
Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis
Genes Cells, February 1, 2006; 11(2): 153 - 162.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
R. Xia, J. Wang, C. Liu, Y. Wang, Y. Wang, J. Zhai, J. Liu, X. Hong, X. Cao, J.-K. Zhu, et al.
ROR1/RPA2A, a Putative Replication Protein A2, Functions in Epigenetic Gene Silencing and in Regulation of Meristem Development in Arabidopsis
PLANT CELL, January 1, 2006; 18(1): 85 - 103.
[Abstract] [Full Text] [PDF]

Home page
 ANN BOT (LOND)Home page
R. T. GRANT-DOWNTON and H. G. DICKINSON
Epigenetics and its Implications for Plant Biology. 1. The Epigenetic Network in Plants
Ann. Bot., December 1, 2005; 96(7): 1143 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
E. A. Wiley, T. Myers, K. Parker, T. Braun, and M.-C. Yao
Class I Histone Deacetylase Thd1p Affects Nuclear Integrity in Tetrahymena thermophila
Eukaryot. Cell, May 1, 2005; 4(5): 981 - 990.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
C. Zhou, L. Zhang, J. Duan, B. Miki, and K. Wu
HISTONE DEACETYLASE19 Is Involved in Jasmonic Acid and Ethylene Signaling of Pathogen Response in Arabidopsis
PLANT CELL, April 1, 2005; 17(4): 1196 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
P. S.C.F. Rocha, M. Sheikh, R. Melchiorre, M. Fagard, S. Boutet, R. Loach, B. Moffatt, C. Wagner, H. Vaucheret, and I. Furner
The Arabidopsis HOMOLOGY-DEPENDENT GENE SILENCING1 Gene Codes for an S-Adenosyl-L-Homocysteine Hydrolase Required for DNA Methylation-Dependent Gene Silencing
PLANT CELL, February 1, 2005; 17(2): 404 - 417.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. Tian, M. P. Fong, J. J. Wang, N. E. Wei, H. Jiang, R. W. Doerge, and Z. J. Chen
Reversible Histone Acetylation and Deacetylation Mediate Genome-Wide, Promoter-Dependent and Locus-Specific Changes in Gene Expression During Plant Development
Genetics, January 1, 2005; 169(1): 337 - 345.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
L. Johnson, S. Mollah, B. A. Garcia, T. L. Muratore, J. Shabanowitz, D. F. Hunt, and S. E. Jacobsen
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications
Nucleic Acids Res., December 14, 2004; 32(22): 6511 - 6518.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Chen, A. S. Belmont, and S. Huang
Upstream binding factor association induces large-scale chromatin decondensation
PNAS, October 19, 2004; 101(42): 15106 - 15111.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
O. Mathieu and J. Bender
RNA-directed DNA methylation
J. Cell Sci., October 1, 2004; 117(21): 4881 - 4888.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
J. BENDER
DNA Methylation of the Endogenous PAI Genes in Arabidopsis
Cold Spring Harb Symp Quant Biol, January 1, 2004; 69(0): 145 - 154.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 2004 by the American Society of Plant Biologists