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Plant Cell, Vol. 12, 1093-1102, July 2000, Copyright © 2000, American Society of Plant Physiologists

Extensive Duplication and Reshuffling in the Arabidopsis Genome

Guillaume Blanca, Abdelali Barakata, Romain Guyota, Richard Cookea, and Michel Delsenya
a Laboratoire Génome et Développement des Plantes, Unité Mixte de Recherche 5096, Centre National de la Recherche Scientifique, University of Perpignan, 66860 Perpignan Cédex, France

Correspondence to: Richard Cooke, cooke{at}univ-perp.fr (E-mail), 33-468668499 (fax)

Systematic analysis of the Arabidopsis genome provides a basis for detailed studies of genome structure and evolution. Members of multigene families were mapped, and random sequence alignment was used to identify regions of extended similarity in the Arabidopsis genome. Detailed analysis showed that the number, order, and orientation of genes were conserved over large regions of the genome, revealing extensive duplication covering the majority of the known genomic sequence. Fine mapping analysis showed much rearrangement, resulting in a patchwork of duplicated regions that indicated deletion, insertion, tandem duplication, inversion, and reciprocal translocation. The implications of these observations for evolution of the Arabidopsis genome as well as their usefulness for analysis and annotation of the genomic sequence and in comparative genomics are discussed.




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