Plant Cell email content delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (48)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dorweiler, J. E.
Right arrow Articles by Chandler, V. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dorweiler, J. E.
Right arrow Articles by Chandler, V. L.
Agricola
Right arrow Articles by Dorweiler, J. E.
Right arrow Articles by Chandler, V. L.
Plant Cell, Vol. 12, 2101-2118, November 2000, Copyright © 2000, American Society of Plant Physiologists

mediator of paramutation1 Is Required for Establishment and Maintenance of Paramutation at Multiple Maize Loci

Jane E. Dorweilera,b, Charles C. Careya,b, Kenneth M. Kubob, Jay B. Hollickb,c, Jerry L. Kermicled, and Vicki L. Chandlera,b
a Plant Sciences Department, University of Arizona, Tucson, Arizona 85721
b Institute of Molecular Biology, University of Oregon, Eugene, Oregon 94703
c Department of Plant and Microbial Biology, University of California, Berkeley, California 94720
d Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706

Correspondence to: Vicki L. Chandler, chandler{at}ag.arizona.edu (E-mail), 520-621-7186 (fax)

Paramutation is the directed, heritable alteration of the expression of one allele when heterozygous with another allele. Here, the isolation and characterization of a mutation affecting paramutation, mediator of paramutation1-1 (mop1-1), are described. Experiments demonstrate that the wild-type gene Mop1 is required for establishment and maintenance of the paramutant state. The mop1-1 mutation affects paramutation at the multiple loci tested but has no effect on alleles that do not participate in paramutation. The mutation does not alter the amounts of actin and ubiquitin transcripts, which suggests that the mop1 gene does not encode a global repressor. Maize plants homozygous for mop1-1 can have pleiotropic developmental defects, suggesting that mop1-1 may affect more genes than just the known paramutant ones. The mop1-1 mutation does not alter the extent of DNA methylation in rDNA and centromeric repeats. The observation that mop1 affects paramutation at multiple loci, despite major differences between these loci in their gene structure, correlations with DNA methylation, and stability of the paramutant state, suggests that a common mechanism underlies paramutation. A protein-based epigenetic model for paramutation is discussed.




This article has been cited by other articles:


Home page
 GeneticsHome page
L. Sidorenko and V. Chandler
RNA-Dependent RNA Polymerase Is Required for Enhancer-Mediated Transcriptional Silencing Associated With Paramutation at the Maize p1 Gene
Genetics, December 1, 2008; 180(4): 1983 - 1993.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Nobuta, C. Lu, R. Shrivastava, M. Pillay, E. De Paoli, M. Accerbi, M. Arteaga-Vazquez, L. Sidorenko, D.-H. Jeong, Y. Yen, et al.
Distinct size distribution of endogenous siRNAs in maize: Evidence from deep sequencing in the mop1-1 mutant
PNAS, September 30, 2008; 105(39): 14958 - 14963.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
X. Zhang
The Epigenetic Landscape of Plants
Science, April 25, 2008; 320(5875): 489 - 492.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
V. Chandler and M. Alleman
Paramutation: Epigenetic Instructions Passed Across Generations
Genetics, April 1, 2008; 178(4): 1839 - 1844.
[Full Text] [PDF]

Home page
 GeneticsHome page
S. M. Gross and J. B. Hollick
Multiple Trans-Sensing Interactions Affect Meiotically Heritable Epigenetic States at the Maize pl1 Locus
Genetics, June 1, 2007; 176(2): 829 - 839.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
K. McGinnis, N. Murphy, A. R. Carlson, A. Akula, C. Akula, H. Basinger, M. Carlson, P. Hermanson, N. Kovacevic, M. A. McGill, et al.
Assessing the Efficiency of RNA Interference for Maize Functional Genomics
Plant Physiology, April 1, 2007; 143(4): 1441 - 1451.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
R. S. Sekhon, T. Peterson, and S. Chopra
Epigenetic Modifications of Distinct Sequences of the p1 Regulatory Gene Specify Tissue-Specific Expression Patterns in Maize
Genetics, March 1, 2007; 175(3): 1059 - 1070.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
X. Cao, L. M. Costa, C. Biderre-Petit, B. Kbhaya, N. Dey, P. Perez, D. R. McCarty, J. F. Gutierrez-Marcos, and P. W. Becraft
Abscisic Acid and Stress Signals Induce Viviparous1 Expression in Seed and Vegetative Tissues of Maize
Plant Physiology, February 1, 2007; 143(2): 720 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
R. Sunkar, A. Kapoor, and J.-K. Zhu
Posttranscriptional Induction of Two Cu/Zn Superoxide Dismutase Genes in Arabidopsis Is Mediated by Downregulation of miR398 and Important for Oxidative Stress Tolerance
PLANT CELL, August 1, 2006; 18(8): 2051 - 2065.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
K. M. McGinnis, C. Springer, Y. Lin, C. C. Carey, and V. Chandler
Transcriptionally Silenced Transgenes in Maize Are Activated by Three Mutations Defective in Paramutation
Genetics, July 1, 2006; 173(3): 1637 - 1647.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
B.-h. Lee, A. Kapoor, J. Zhu, and J.-K. Zhu
STABILIZED1, a Stress-Upregulated Nuclear Protein, Is Required for Pre-mRNA Splicing, mRNA Turnover, and Stress Tolerance in Arabidopsis
PLANT CELL, July 1, 2006; 18(7): 1736 - 1749.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. R. Woodhouse, M. Freeling, and D. Lisch
The mop1 (mediator of paramutation1) Mutant Progressively Reactivates One of the Two Genes Encoded by the MuDR Transposon in Maize
Genetics, January 1, 2006; 172(1): 579 - 592.
[Abstract] [Full Text] [PDF]

Home page
 ANN BOT (LOND)Home page
R. T. GRANT-DOWNTON and H. G. DICKINSON
Epigenetics and its Implications for Plant Biology. 1. The Epigenetic Network in Plants
Ann. Bot., December 1, 2005; 96(7): 1143 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. B. Hollick, J. L. Kermicle, and S. E. Parkinson
Rmr6 Maintains Meiotic Inheritance of Paramutant States in Zea mays
Genetics, October 1, 2005; 171(2): 725 - 740.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J. T. Leiva-Neto, G. Grafi, P. A. Sabelli, R. A. Dante, Y.-m. Woo, S. Maddock, W. J. Gordon-Kamm, and B. A. Larkins
A Dominant Negative Mutant of Cyclin-Dependent Kinase A Reduces Endoreduplication but Not Cell Size or Gene Expression in Maize Endosperm
PLANT CELL, July 1, 2004; 16(7): 1854 - 1869.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
C. B. Della Vedova and K. C. Cone
Paramutation: The Chromatin Connection
PLANT CELL, June 1, 2004; 16(6): 1358 - 1364.
[Full Text] [PDF]

Home page
 Plant CellHome page
C. C. Carey, J. T. Strahle, D. A. Selinger, and V. L. Chandler
Mutations in the pale aleurone color1 Regulatory Gene of the Zea mays Anthocyanin Pathway Have Distinct Phenotypes Relative to the Functionally Similar TRANSPARENT TESTA GLABRA1 Gene in Arabidopsis thaliana
PLANT CELL, February 1, 2004; 16(2): 450 - 464.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
V.L. CHANDLER
Poetry of b1 Paramutation: cis- and trans-Chromatin Communication
Cold Spring Harb Symp Quant Biol, January 1, 2004; 69(0): 355 - 362.
[Abstract] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
C. SPILLANE, C. BAROUX, J.-M. ESCOBAR-RESTREPO, D.R. PAGE, S. LAOUEILLE, and U. GROSSNIKLAUS
Transposons and Tandem Repeats Are Not Involved in the Control of Genomic Imprinting at the MEDEA Locus in Arabidopsis
Cold Spring Harb Symp Quant Biol, January 1, 2004; 69(0): 465 - 476.
[Abstract] [PDF]

Home page
 GeneticsHome page
R. K. Slotkin, M. Freeling, and D. Lisch
Mu killer Causes the Heritable Inactivation of the Mutator Family of Transposable Elements in Zea mays
Genetics, October 1, 2003; 165(2): 781 - 797.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. Chopra, S. M. Cocciolone, S. Bushman, V. Sangar, M. D. McMullen, and T. Peterson
The Maize Unstable factor for orange1 Is a Dominant Epigenetic Modifier of a Tissue Specifically Silent Allele of pericarp color1
Genetics, March 1, 2003; 163(3): 1135 - 1146.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
G. Drugeon and I. Jupin
Stability in vitro of the 69K movement protein of Turnip yellow mosaic virus is regulated by the ubiquitin-mediated proteasome pathway
J. Gen. Virol., December 1, 2002; 83(12): 3187 - 3197.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. Stam, C. Belele, W. Ramakrishna, J. E. Dorweiler, J. L. Bennetzen, and V. L. Chandler
The Regulatory Regions Required for B' Paramutation and Expression Are Located Far Upstream of the Maize b1 Transcribed Sequences
Genetics, October 1, 2002; 162(2): 917 - 930.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Stam, C. Belele, J. E. Dorweiler, and V. L. Chandler
Differential chromatin structure within a tandem array 100 kb upstream of the maize b1 locus is associated with paramutation
Genes & Dev., August 1, 2002; 16(15): 1906 - 1918.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Lisch, C. C. Carey, J. E. Dorweiler, and V. L. Chandler
A mutation that prevents paramutation in maize also reverses Mutator transposon methylation and silencing
PNAS, April 30, 2002; 99(9): 6130 - 6135.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
N. A. Eckardt, H.-T. Cho, R. M. Perrin, and M. R. Willmann
Plant Biology 2001
PLANT CELL, October 1, 2001; 13(10): 2165 - 2173.
[Full Text] [PDF]

Home page
 Plant Physiol.Home page
D. R. Lisch, M. Freeling, R. J. Langham, and M. Y. Choy
Mutator Transposase Is Widespread in the Grasses
Plant Physiology, March 1, 2001; 125(3): 1293 - 1303.
[Abstract] [Full Text]

Home page
 GeneticsHome page
J. B. Hollick and V. L. Chandler
Genetic Factors Required to Maintain Repression of a Paramutagenic Maize pl1 Allele
Genetics, January 1, 2001; 157(1): 369 - 378.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Lisch, C. C. Carey, J. E. Dorweiler, and V. L. Chandler
A mutation that prevents paramutation in maize also reverses Mutator transposon methylation and silencing
PNAS, April 30, 2002; 99(9): 6130 - 6135.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 2000 by the American Society of Plant Biologists